Global Regulatory and Public Health Initiatives to Advance Pediatric Drug Development for Rare DiseasesArticle Published on 2022-11-012022-11-16 Journal: Therapeutic innovation & regulatory science [Category] 신약개발, [키워드] advance affected approach children clinical trials COVID-19 COVID-19 pandemic development disease drug ecosystem Efficacy effort engage equity facilitate Follow-up include initiative key factor lack outcome measure Patient pediatric pediatric drug development promote Public public health rare disease rare diseases Regulatory Regulatory policy. Study design Therapies Trial trials [DOI] 10.1007/s43441-022-00409-w PMC 바로가기
Body weight, dietary intake, and health risk factors pre-COVID and during the COVID-19 pandemicResearch article Published on 2022-11-012022-10-05 Journal: Appetite [Category] 임상, 진단, 치료기술, [키워드] 2020 COVID-19 pandemic Administered appear body weight changes in cholesterol clinical clinical risk factor collected COVID COVID-19 COVID-19 pandemic decrease Diastolic blood pressure diet dietary intake fat Fat mass food Food Intake Fruit and vegetable intake Health Health risk factors hospital increase measure outcome measure risk factor Risk factors weight [DOI] 10.1016/j.appet.2022.106182 [Article Type] Research article
An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 임상, [키워드] 1:1 adverse event Analysis Anxiety approach approaches assigned Block randomisation breathlessness chronic obstructive clinically clinics complementary computer-generated conducted COVID COVID-19 eight element English Generalised anxiety disorder groups Health Imperial College London IMPROVE improvement individual intention-to-treat population Intervention Mental mental health MHC outcome measure parallel-group participant participated Patient physical potential participant Primary outcome pulmonary disease qualitative data randomisation randomised controlled trial Randomly recovering from COVID-19 recruited Registered reported Research researcher responses responsible secondary secondary outcome single-blind statistically significant Symptom thematic analysis treatment group Trial unique usual care usual care group Visual Analogue Scale was done were excluded were given [DOI] 10.1016/S2213-2600(22)00125-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
A First View of the Effect of a Trial of Early Mobilization on the Muscle Strength and Activities of Daily Living in Mechanically Ventilated Patients With COVID-19Research article Published on 2022-09-012022-10-05 Journal: Archives of Rehabilitation Research and Clinical Translation [Category] 임상, [키워드] Activities of Daily Living activity Barthel Index Care COVID-19 Daily daily living Early Ambulation Effect functional groups Inpatient intensive care Intervention Japan male manual measure mechanical ventilation Medical Research Council Mobility mobilization muscle Muscle strength no difference objective outcome measure participant Patient patients with COVID-19 postintervention rehabilitation Respiration Result retrospective scale setting severe COVID-19 significantly single-center small sample size statistically significant strength subject Test View [DOI] 10.1016/j.arrct.2022.100201 [Article Type] Research article
Harvest for Health, a Randomized Controlled Trial Testing a Home-Based, Vegetable Gardening Intervention Among Older Cancer Survivors Across Alabama: An Analysis of Accrual and Modifications Made in Intervention Delivery and Assessment During COVID-19Research article Published on 2022-09-012022-10-05 Journal: Journal of the Academy of Nutrition and Dietetics [Category] 임상, [키워드] analysis anticipated approach assessment assigned Baseline assessment Breast cancer Cancer Controlled COVID-19 COVID-19 pandemic cross-over delivery diet dissemination Effect eligible enrolled Enrollment Evidence female functional gardening Harvest Health IMPROVE indicated Intervention Modification not differ objective Older Older adults outcome outcome measure participant performed physical physical activity Physical function populations primary end point protocol Quality of life Randomized Randomized controlled trial Randomly RCT recruited recruitment reported Result screened significantly higher survival survivor Survivors survivorship T Test Testing Trial vegetable were used widespread [DOI] 10.1016/j.jand.2022.05.005 [Article Type] Research article
Traditional Chinese medicine treatment for COVID-19: An overview of systematic reviews and meta-analysesCovid-19에 대한 전통 중국 의약 치료 : 체계적인 검토 및 메타 분석의 개요Review Published on 2022-09-012022-08-31 Journal: Journal of integrative medicine [Category] meta-analysis, 임상, 치료법, [키워드] addition Analysis assessment can be used caused China Chinese Chinese traditional Chongqing clinical decision Clinical efficacy clinical outcomes clinical trial clinical trials Cochrane Library Combination control group conversion coronavirus disease Coronavirus disease 2019 COVID-19 data extraction Decision making defined development duration of symptoms Efficacy evaluate evaluated Evidence evidence of examined Factors Hospital stay improve clinical outcomes indicated Infrastructure integrative medicine intervention group lung measurement Medicine meta-analyses Meta-analysis meta-analysis Methodological quality moderate Mortality outcome outcome measure performed proliferation Randomized controlled trial Randomized controlled trials rapidly spreading disease review searched SinoMed Symptom systematic review systematic review. systematic reviews TCM therapy Traditional Chinese medicine Treatment Version VIP was used Web of Science were used [DOI] 10.1016/j.joim.2022.06.006 PMC 바로가기 [Article Type] Review
Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort StudyResearch article Published on 2022-09-012022-10-05 Journal: American journal of obstetrics and gynecology [Category] 진단, [키워드] 95% confidence interval Admission Analysis association birthweight Breastfeeding Care carried cesarean delivery Cohort cohort study complications condition Contact correlated correlation COVID-19 COVID-19 diagnosis COVID-19 symptoms death Diagnosis diagnosis of COVID-19 disorder distress Effect enrolled evaluate feeding problems fetal Fever gestational diabete health condition hospital hospital discharge Hospital stay hypertensive increased risk infections intensive care intrauterine growth restriction laboratory confirmation Logistic Maternal morbidity morbidity and mortality Mortality mother multicenter study multivariable Neonatal neonatal intensive care unit admission Neonatal outcomes Neonate neurologic outcome Newborn objective Odds ratio outcome outcome measure perinatal practices positive preeclampsia Pregnancy prenatal Preterm birth radiological Respiratory Support respiratory symptoms Result risk risk factor risk ratio Rooming-in SARS-CoV-2 SARS-CoV-2 exposure severity significantly skin-to-skin small for gestational age tested took place Transmission Vaginal was determined with COVID-19 women worsened [DOI] 10.1016/j.ajog.2022.04.019 [Article Type] Research article
Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial Research Published on 2022-08-082022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, 치료법, [키워드] 1:1 95% confidence interval antibody assessment baseline blockade Cambridge carrier cognitive Cohort diagnosed disease double-blind Efficacy Endpoint enrolled evaluate Frequency magnetic resonance imaging measure multicenter outcome outcome measure Participants Patient phase 2 trial Placebo placebo-controlled positive Primary outcomes Randomized receive SEMA4D Tapping tomography Treatment treatment-emergent adverse event Trial volumetric [DOI] 10.1038/s41591-022-01919-8 [Article Type] Research
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational studyObservational Study Published on 2022-08-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] age analysed approach association Characteristics clinical Clinical outcome clinical trials Cluster cluster analysis Clustering Clusters Cognitive impairment Cohort comparison Concentration COVID COVID-19 described discharge discharged domains effective Factor female full recovery Health hospital Hospital admission hospital discharge hospitalisation identify IL-6 improvement Inflammation Inflammatory inflammatory mediator Innovation Intervention Invasive mechanical ventilation ISRCTN registry less logistic regression modelling longitudinal cohort study median men mental health Mild moderate obesity Odds ratio organ function outcome measure outcome measures participant Participants Patient pharmacological PHOSP-COVID physical plasma Post-hospitalisation COVID-19 study potential therapeutic target profile proportion prospective observational study Protein Quality of life recruitment Registered reported retrospective severity Sex stratified tissue damage treatable utility was done was increased was performed was reduced were assessed WHO with COVID-19 women [DOI] 10.1016/S2213-2600(22)00127-8 PMC 바로가기 [Article Type] Observational Study
Psychometric properties of the Spanish version of the EuroQol-5D-5L in previously hospitalized COVID-19 survivors with long COVID Research Published on 2022-07-232022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 95%CI Alpha Analysis calculated coefficient construct validity COVID COVID-19 Cronbach’s alpha Effect hospital discharge Hospitalized hospitalized COVID-19 individual internal internal consistency long-COVID Omega outcome measure psychometric property Quality of life questionnaire ranged reliability Spanish survivor Symptom total score [DOI] 10.1038/s41598-022-17033-1 [Article Type] Research